THE EFFECT OF WATER EXTRACT OF COLA NITIDA POD ON LIPOPROTEIN CONCENTRATIONS OF ALBINO WISTAR RATS

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TABLE OF CONTENT

 

Title page

 

Approval page –   –        –        –        –        –        –        –        i

Dedication – –       –        –        –        –        –        –        –        ii

 

Acknowledgment –         –        –        –        –        –        –        iii

Abstract –   –        –        –        –        –        –        –        –        iv

Table of contents – –       –        –        –        –        –        –        v

 

CHAPTER ONE

1.0 Introduction – –        –        –        –        –        –        –        1

 

CHAPTER TWO

2.0     Literature Review –        –        –        –        –        –        2

 

2.1     Kola Nut Powered (Cola Nitida) –     –        –        –        2

2.2     Kola pod components – –        –        –        –        –        3

2.3     Geography and distribution –  –        –        –        –        4

 

2.4     Lipoprotein –        –        –        –        –        –        –        5

2.5     High cholesterol diagnosis –    –        –        –        –        9

2.6     Low cholesterol –  –        –        –        –        –        –        9

 

 

 

 

 

2.7     Changes during circulation –    –        –        –        –        12

2.8     Liver –         –        –        –        –        –        –        –        13

 

CHAPTER THREE     Materials and methods

3.1     Identification and Extraction plant material –      –        16

3.2     Phytochemical Analysis –        –        –        –        –        17

 

3.3     Experimental Animal model – –        –        –        –        22

3.4     Collection of Blood samples – –        –        –        –        24

3.5     Lipid profile Analysis –  –        –        –        –        –        24

CHAPTER FOUR           Results

 

Phytochemical composition of samples –   –        –        –        31

CHAPTER FIVE            Discussion and conclusion

5.1     Discussion – –       –        –        –        –        –        –        34

 

5.2     Conclusion —        –        –        –        –        –        –        35

 

 

Reference   – –       –        –        –        –        –        –        –        36

 

 

 

 

 

ABSTRACT

Cola nitida has been in use in the eastern parts of Nigeria for the
management  of  certain  ailments  and  as  an  aphrodisiac  in  the
management of some sexual dysfunctions. However the effects of this
extract in some health parameters in human objects have not been
reported. This work, then, was aimed at investigating the effect of
water extracts of kola pods on lipoprotein concentrations on albino
wistar rats.

Rats were used in this study and they were divided into several groups and fed with a high calorie food (cow’s brain) so as to increase the blood lipoprotein concentration in the rat models. The effect of the water extracts of the sample used was compared with a known drug and the results statistically compared to ascertain the effect of the water extract on the rat models.

The results of this work indicate that water extracts of cola nitida pods can be used in the management of mild lipoprotein dysfunctions thus substantiating the reasons for its use in sexual erectile functions.

 

 

 

 

 

CHAPTER ONE

 

1.1     INTRODUCTION

Cola Nitida has been used in folk medicine as an aphrodisiac,
an appetite suppressant, to treat morning sickness, migraine headache,
and  indigestion (Esimone  et  al., 2007).  It  has  also  been  applied

directly to the skin to treat wounds and inflammation (Newall et al., 1996)on the teeth and gums. There has also been speculations as to its use in the treatment of peptic ulcer, however, in Nigeria there is no record of the incidence of peptic ulcer.

According to Esimone (2007), cola nitida tree is native to West
Africa. Cola nuts are obtained from cola trees. Cola nitida belongs to
the genus cola and family steriliaceae.   They are commonly used to
counteract hunger and thirst;  in some cases it is used to control
vomiting in pregnant woman and also as a principal stimulant to keep
awake and withstand fatigue by students, drivers, and other menial
workers.

Lipoproteins are found in the liver and cells. The liver is the
largest organ inside the body. The liver is dark reddish-brown and

 

 

 

consists of two main lobes. There are over 300 billion specialized cells in the liver that are connected by a well organized system of “bile” ducts and blood vessels called the biliary system.

 

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